Tadalista

Tadalista (active substance tadalafil citrate) is a drug used orally as needed before planned sexual activity in order to retrieve the lost or compromised ability to develop erectile hardness in response to sexual stimulation.

Tadalista is a generically produced version of tadalafil, which is universally recognized under the brand name of Cialis, the “weekend pill”. The drug’s moniker derives from its outstanding phacmacodynamic feature of supreme efficacy window that lasts for 36 hours after the moment of effect onset.

Tadalista and Cialis are interchangeable in the majority of instances, when the dosage coincides (the former is available in a single dose of tadalafil 20mg, while the original preparation dosage range is more diversified and comprises of 2.5mg, 5mg, 10mg and 20mg pills).

Tadalista is an oral drug used to improve erectile function by enhancing the effect of nitric oxide (NO), the main mediator of penile erection. Tadalista is one of the class of drugs called inhibitors phosphodiesterase type 5. These drugs, in fact, by inhibiting the enzyme phosphodiesterase 5 (PDE5), cause the relaxation of the smooth muscle cells of the penis to be amplified, guaranteeing a more rigid and lasting erection.

By inhibiting PDE5, sildenafil, vardenafil and tadalafil obtain the effect of amplifying the action of NO and therefore enhancing the physiological mechanism of erection. The PDE5i, therefore, do not directly induce an erection, but rather optimize the mechanism in the presence of a physiological stimulus. Therefore, for PDE5i to work, there must be at least a minimal endogenous production of NO. The mechanism of action is similar for all three drugs, which have shown in important clinical studies to be effective and well tolerated.

Tadalista is manufactured in India by a certified pharmaceutical company Fortune Healthcare Pvt. Ltd. with years of expertise in generic drug manufacture. Being a generic equivalent of the world’s best selling drug, Tadalista costs significantly less than the original drug. The rationale behind the drug’s affordability is the price formation rules for generic drugs, which include the cost of production and logistics (the original drug prices also incur the investments in the research and promotion phase).

The response window for tadalafil is estimated between 30 and 40 minutes, but in practice the onset time is affected by a number of factors which can both speed it up or delay it. These are:

• the timing of the last meal taken
• the presence / absence of alcohol in the blood plasma
• patient’s age
• patient’s physique and fitness level
• general health condition of the patient
• concomitant use of certain other drugs

Tadalista is a high quality generic medication produced in accordance to ISO 9000:2001 and Good Manufacturing Practice guidelines that ensure the safety of the final product. As for the active substance of the drug, tadalafil, its safety in both short-term application and long-term use have been proven by dozens of patient-years. You can find the results of tadalafil safety studies here.

During the years of tadalafil existence, millions of patients around the world have taken the drug in its brand and generic forms, demonstrating in the field that they are safe drugs, even if they are taken repeatedly over the long term, as long as the warnings and contraindications on the package insert are respected. Although the efficacy and safety profile of PDE5i are optimal, their use must take place under the guidance and control of a specialist doctor.

Viagra, the first PDE5 inhibitor, was introduced on the market in 1998. Viagra contains the active substance sildenafil. In the following years two other drugs were added: vardenafil and tadalafil.

The duration of action, ie the time frame in which the erection will be facilitated and improved, varies with the three different drugs depending on their half-life, but is however strongly variable from one patient to another. In any case, in subjects who respond to therapy, the duration is never less than 4 hours, and with the drug with longer half-life (tadalafil) it can exceed 36 hours.

PDE5 inhibitors are today the first therapeutic choice in almost all forms of erectile dysfunction, effective and well tolerated in over 70% of ED cases. Obviously, not all cases of erectile dysfunction are the same. We know that ED can be of different etiology and severity, and the efficacy of PDE5 can vary in different categories of patients. However, there is no form or type of erectile dysfunction in which PDE5 inhibitors are not effective, at least in a minority of patients. For this reason, whatever the type of ED, most specialists consider other treatment options only after these oral medications have proven ineffective.

The undesirable effects of tadalafil are similar to those of other phosphodiesterase inhibitors: during the studies headache, flushing of the face, back pain, dyspepsia, nasal congestion, nausea, abdominal pain, dizziness, myalgia were reported more frequently. Undesirable effects are dose-dependent and predominantly mild. At the moment the data are insufficient to assess long-term undesirable effects in groups of patients with high cardiovascular risk. The undesirable effects are closely related to the mechanism of pharmacological action of inhibition of phosphodiesterase type 5. This isoenzyme is not present exclusively in the corpora cavernosa, although it is predominant here, and also intervenes in other metabolic pathways. Furthermore, due to the inhibitory activity on PDE 6, which is found in high concentration in the retinal cells, visual disturbances may occur even if with low frequency. Like sildenafil, tadalafil also has the potential to decrease blood pressure, which could be a problem in patients treated with antihypertensives.

By intervening on the NO / cGMP metabolic cycle, vardenafil enhances the hypotensive effect of nitrates and its administration is contraindicated in patients who are taking nitrates in any pharmaceutical formulation. It is also contraindicated in patients with recent history of stroke and heart attack and, for possible vision disorders, even in patients with degenerative retinal diseases such as retinitis pigmentosa. Tadalista should not be used in patients with severe hepatic impairment.

Clinically relevant hypotension may occur in patients taking non-selective alpha blockers. Interactions with any drug inhibitor of the CYP3A4 enzyme system (eg erythromycin, azole antifungals, indinavir) are possible. There are no interactions with food and alcohol.

Tadalista should not be used in individuals suffering from:

• heart disease
• high blood pressure
• low blood pressure
• ulcerative disease of stomach or duodenum
• renal or hepatic dysfunctions
• retinitis pigmentosa, NAION
• Peyronie’s disease, Priapism
• sickle cell anemia, leukemia, multiple myeloma

Verify the full list of Tadalista contraindications with your prescriber and keep them informed about your past and current medical conditions, as well as give them a full list of pharmacological substances (prescription, OTC and food supplements) you are currently using.

In the US and other countries where the patent for exclusive production of Cialis has not yet expired, Tadalista is available for sale exclusively online. Note that Tadalista is a prescription drug that requires medical consultation and approval before you order Tadalista online; however, multiple services operating as international pharmacies offer free medical consultations online by board-certified doctors.